SARS-CoV-2 mutagenesis – Communicable Diseases Research

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

SARS-CoV-2에 의한 폐 감염은 심각한 COVID-19에서 염증성 표현형과 함께 노화를 유도합니다: 바이러스 돌연변이 유발 가능성

Article

Published on 2022-08-182022-09-11
Journal: The European Respiratory Journal
[Category] Fulltext, SARS, 진단, 치료기술,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus alveolar analysed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 APOBEC Apolipoprotein B AT2 Cell cells cellular senescence chronic inflammation Comorbidity Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL8 cytokine Cytokines demonstrated disease DNA damage electron microscopy enzyme Enzymes epithelial exhibited expressed expression extrapulmonary sites H2Ax IL-1β IL-6 IL-6 expression immunocytochemistry immunohistochemistry implication in vitro induce infecting Infection Inflammation inflammatory phenotype Inflammatory response investigated kidney liver lung tissue sample marker Microscopy molecular mechanism multisystemic disease Mutagenesis Non-COVID-19 persistence phenotype progeny proinflammatory promote pulmonary respiratory Respiratory system SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutagenesis SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains SASP senescence senescent cell Sequencing analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Strains Vero-E6 cell Vero-E6 cells Viral mutagenesis
[DOI] 10.1183/13993003.02951-2021 PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection

감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.

Clinical Trial

Published on 2022-01-122022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, 변종, 임상, 치료기술, 치료법,

[키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern
[DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

몰누피라비르 유발 SARS-CoV-2 돌연변이 유발 메커니즘

Article

Published on 2021-08-112022-09-10
Journal: Nature Structural & Molecular Biology
[Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] (RdRp (RdRp) active form Analysis animal model animal models antiviral activity antiviral drug base pair base pairs biochemical assay cause complexes COVID-19 Cryo-EM analysis Cryoelectron microscopy cytidine cytidine triphosphate explain Frequency High-resolution humans impair incorporation increase mechanism molecular mechanism molecular mechanisms molnupiravir Mutagenesis mutated Mutation NHC patients with COVID-19 phase III trial Phase III trials polymerase Proofreading RdRP resulting RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 mutagenesis SARS-CoV-2 replication Structural analysis substrate Template Treatment triphosphate uridine uridine triphosphate Viral Viral mutagenesis Viral RNA viral RNA-dependent RNA polymerase
[DOI] 10.1038/s41594-021-00651-0 PMC 바로가기 [Article Type] Article